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Transposition of the Great Arteries 

What is Transposition of the Great Arteries (TGA)?

Transposition of the great arteries (TGA) is a congenital heart defect where the aorta and pulmonary artery are switched. This changes the way blood circulates through the body causing oxygen-poor blood to flow to the body.

How is TGA diagnosed and monitored during pregnancy?

If your doctor suspects a fetal heart anomaly after reviewing your routine ultrasound, he or she may request a fetal echocardiogram (echo), an ultrasound of the fetus’s heart. This safe, noninvasive test shows the structure of the heart and how it is functioning, which can help us confirm the diagnosis of TGA and discuss possible options for treatment after delivery. Our Fetal Heart Team will monitor the baby closely for the remainder of the pregnancy.

How does TGA affect delivery and after birth?

Most babies with TGA can be delivered vaginally at full term unless otherwise indicated by your obstetrician. It is best for these babies to be delivered at a medical center where there is access to a team of pediatric cardiologists and neonatologists, along with an established Neonatal Intensive Care Unit (NICU).

After delivery, the baby will need prostaglandin (PGE), an intravenous medication that keeps the patent ductus arteriosus (a normal connection present in babies in the womb) open. The patent ductus arteriosus (PDA) will allow some mixing of oxygenated and unoxygenated blood.

What are the treatments and surgeries for TGA?

Medical treatment with PGE is required for all babies with TGA.

At birth, every baby has a patent foramen ovale (PFO), a small hole between the top chambers of the heart (the right and left atria). In TGA, the PFO is very important to allow mixing of oxygenated and unoxygenated blood. If the PFO is not big enough, a cardiac catheterization may be required to perform a balloon atrial septostomy in the first few days of life. This X-ray guided procedure is typically done by placing a thin flexible tube, or catheter, through the umbilical vein (a vessel in the umbilical cord) and does not require an incision. A balloon atrial septostomy creates a larger hole between the top chambers of the heart. The procedure is performed in the pediatric hybrid cardiac catheterization suite at Cardinal Glennon.

The surgical approach for TGA depends on the baby’s anatomy. The most common procedure is the arterial switch. In this open-heart surgery, the pulmonary artery and aorta are switched back to their normal positions.

What happens after surgery?

After surgery the baby will require a stay in the Neonatal or Pediatric Intensive Care Unit (NICU or PICU) until they overcome any feeding and breathing difficulties. Following surgery these children will need lifelong follow-up visits with a cardiologist.

What is the long-term prognosis?

With early diagnosis and treatment, many children born with TGA live healthy and normal lives. In some cases children may develop narrowing of the pulmonary arteries, which might require further treatment which is typically done by cardiac catheterization.

Additional Resources:

Congenital Heart Disease Resource Page
Provided by the Dorothy and Larry Dallas Heart Center at SSM Health Cardinal Glennon Children's Hospital

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